Introduction: unmarried and unknown: urban men and women in the low countries since the early modern period

This essay introduces a special issue on The Lure of the City that examines the attraction of towns to unmarried men and women in the Low Countries during the early modern period and the nineteenth century. The issue has the relation between singles and cities as its main focus. Singles were present in disproportionately large numbers in urban areas, but the question is why? This essay sets out the historiographical framework for the contributions in the issue, discusses the sources and methodologies used, and provides a brief overview of the evolution of singleness in the Low Countries. The contributions all demonstrate the relevance of a comparative approach. It is revealed that towns and cities not only attracted but also created singles, that they offered different opportunities for different groups of unmarried people and that they affected men and women differently. Finally, it appears that not every town and city was attractive to men and women without a spouse

At Home in Renaissance Bruges

How did citizens in Bruges create a home? What did an ordinary domestic interior look like in the sixteenth century? And more importantly: how does one study the domestic culture of bygone times by analysing documents such as probate inventories? These questions seem straightforward, yet few endeavours are more challenging than reconstructing a sixteenth-century domestic reality from written sources. This book takes full advantage of the inventory as a source and convincingly frames household objects in their original context of use. Meticulously connecting objects, people and domestic spaces, the book introduces the reader to the rich material world of Bruges citizens in the Renaissance, their sensory engagement, their religious practice, the daily activities of men and women, and other social factors. By weaving insights from material culture studies with urban history, At Home in Renaissance Bruges offers an appealing and holistic mixture of in-depth socio-economic, cultural and material analysis. In its approach the book goes beyond heavy-handed theories and stereotypes about the exquisite taste of aristocratic elites, focusing instead on the domestic materiality of Bruges’ middling groups. Evocatively illustrated with contemporary paintings and images of furniture and textiles from Bruges and beyond, this monograph shows a nuanced picture of domestic materiality in a remarkable European city

At Home in Renaissance Bruges

How did citizens in Bruges create a home? What did an ordinary domestic interior look like in the sixteenth century? And more importantly: how does one study the domestic culture of bygone times by analysing documents such as probate inventories? These questions seem straightforward, yet few endeavours are more challenging than reconstructing a sixteenth-century domestic reality from written sources. This book takes full advantage of the inventory as a source and convincingly frames household objects in their original context of use. Meticulously connecting objects, people and domestic spaces, the book introduces the reader to the rich material world of Bruges citizens in the Renaissance, their sensory engagement, their religious practice, the daily activities of men and women, and other social factors. By weaving insights from material culture studies with urban history, At Home in Renaissance Bruges offers an appealing and holistic mixture of in-depth socio-economic, cultural and material analysis. In its approach the book goes beyond heavy-handed theories and stereotypes about the exquisite taste of aristocratic elites, focusing instead on the domestic materiality of Bruges’ middling groups. Evocatively illustrated with contemporary paintings and images of furniture and textiles from Bruges and beyond, this monograph shows a nuanced picture of domestic materiality in a remarkable European city

Psychological Conditions in Adults With Diabetes.

Type 1 (T1D) and Type 2 diabetes (T2D) represent a demanding set of biopsychosocial challenges for patients and their families, whether the age of disease onset occurs in childhood, adolescence, or adulthood. Psychological conditions, defined as syndromes, disorders, and diabetes-specific psychological issues affect a larger proportion of individuals with T1D and T2D compared to the general population. In this review, we summarize the prevalence, impact and psychological treatments associated with the primary categories of psychological conditions that affect adults with T1D and T2D: depressive symptoms and syndromes, anxiety disorders, eating behaviors and disorders and serious mental illness. The implications of the literature for psychologists are discussed, and priorities for future research to advance the science of psychological conditions for adults with T1D and T2D are identified

Racial and Ethnic Disparities in Diabetes Complications in the Northeastern United States: The Role of Socioeconomic Status

The role of socioeconomic status (SES) in explaining racial/ethnic disparities in diabetes remains unclear. We investigated disparities in self-reported diabetes complications, and the role of macro (e.g., income, education) and micro (e.g., ‘owning a home’ or ‘having a checking account’) SES indicators in explaining these differences. The sample included individuals with a diagnosis of diabetes (N=795) who were on average 55 years old, and 55.6% non-Hispanic White, 25.0% African American, and 19.4% Hispanic. Approximately 8% reported nephropathy, 35% reported retinopathy, and 16% reported cardiovascular disease. There were significant disparities in the rates of complications among non-Hispanic White, African American and Hispanic participants, with Hispanics having the highest rates of nephropathy, retinopathy, and cardiovascular disease. Macro SES indicators (e.g., income) mediated racial differences (i.e., non-Hispanic Whites vs. African Americans) in self-reported retinopathy, a combination of macro and more micro SES indicators (e.g., education, income, and ‘owning a home’ or ‘having a checking account’) mediated racial/ethnic differences (i.e., non-Hispanic Whites vs. Hispanics) in self-reported cardiovascular disease, and only micro SES indicators (e.g., ‘owning a home’ or ‘having a checking account’) mediated differences between lower income SES racial/ethnic minority groups (i.e., African Americans vs. Hispanics) in self-reported retinopathy and cardiovascular disease. Findings underscore that indicators of SES must be sensitive to the outcome of interest and the racial/ethnic groups being compared

Epitope-based vaccination against pneumonic tularemia

Francisella tularensis, the etiological agent of tularemia, is one of the most infectious bacterial pathogens known. No vaccine is currently approved for public use. Previously, we identified epitopes recognized specifically by T cells obtained from individuals following infection with F. tularensis. Here, we report that a subunit vaccine constructed based upon these epitopes elicited protective immunity in “humanized” HLA class II (DRB1*0401) transgenic mice. Vaccinated mice challenged intratracheally with a lethal dose of F. tularensis (Live Vaccine Strain) exhibited a rapid increase in pro-inflammatory cytokine production and diminished number of organisms in the lungs, and a concurrent increased rate of survival. These results demonstrate the efficacy of an epitope-based tularemia vaccine and suggest that such an approach might be widely applicable to the development of vaccines specific for intracellular bacterial pathogens

Mesothelin/CD3 half-life extended bispecific T-cell engager molecule shows specific tumor uptake and distributes to mesothelin and CD3 expressing tissues

BiTE ® (bispecific T-cell engager) molecules exert antitumor activity by binding one arm to CD3 on cytotoxic T-cells and the other arm to a tumor-associated antigen. We generated a fully mouse cross-reactive mesothelin (MSLN)-targeted BiTE molecule that is genetically fused to a Fc-domain for half-life extension, and evaluated biodistribution and tumor targeting of a zirconium-89 (89Zr)-labeled MSLN HLE BiTE molecule in 4T1 breast cancer bearing syngeneic mice with positron emission tomography (PET). Biodistribution of 50 µg 89Zr-MLSN HLE BiTE was studied over time by PET imaging in BALB/c mice and revealed uptake in tumor and lymphoid tissues with an elimination half-life of 63.4 hours. Compared to a non-targeting 89Zr-control HLE BiTE, the 89Zr-MLSN HLE BiTE showed a 2-fold higher tumor uptake and higher uptake in lymphoid tissues. Uptake in the tumor colocalized with mesothelin expression, while uptake in the spleen colocalized with CD3 expression. Evaluation of the effect of protein doses on the biodistribution and tumor targeting of 89Zr-MSLN HLE BiTE revealed for all dose groups that uptake in the spleen was faster than in the tumor (day 1 vs day 5). The lowest dose of 10 µg 89Zr-MSLN HLE BiTE had higher spleen uptake and faster blood clearance compared to higher doses of 50 µg and 200 µg. 89Zr-MSLN HLE BiTE tumor uptake was similar at all doses. Conclusion: The MSLN HLE BiTE showed specific tumor uptake and both arms contributed to the biodistribution profile. These findings support the potential for clinical translation of HLE BiTE molecules